HETerogeneous bulk tumors

The Goal

To estimate the gene expression levels and component proportions of the normal, stroma (immune) and tumor components of bulk tumor RNA-Seq samples. Although DisHet is designed for dissection of bulk tumor samples using matched normal tissue and tumorgraft RNA-seq data, it is widely applicable to dissection of gene expression of any mixture of 3 types of cells.

Quick Link:

To read more about DisHet and download it, please download the source files and instruction manual . here. If you have any problems using DisHet Online Tool, please contact us for assistance.

The Authors:


"An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors"